کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5371881 1503967 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Poisson-Boltzmann model analysis of binding mRNA cap analogues to the translation initiation factor eIF4E
چکیده انگلیسی

The electrostatic free energy of binding of two analogues of the 5′-mRNA cap, differing in size and electric charge, to the wild type and mutated eukaryotic initiation factor eIF4E was computed using the finite difference solutions to the Poisson-Boltzmann equation. Two definitions of the solute-solvent dielectric boundary were used: van der Waals model, solvent exclusion (SE) model. The computed electrostatic energies were supplemented by estimations of the non polar and entropic contributions. A comparison with experimental data for the investigated systems was done. It appears that the SE model with additional contribution fits experimental findings better than the van der Waals model does.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 140, Issues 1–3, March 2009, Pages 16-23
نویسندگان
, , ,