کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5371968 | 1503973 | 2008 | 5 صفحه PDF | دانلود رایگان |
In this work we study the colloidal osmotic pressure (COP) and aggregate shape in phosphate saline buffer solutions (pH 7.4) containing bovine serum albumin (BSA), poly(ethylene glycol) lipid (PEG2000-PE) and Dextran (Dx). Dx was added to the BSA/PEG2000-PE system in order to increase the COP of the solution to levels comparable to the COP of healthy adults, with the aim of using the solution as a blood COP regulator. Dynamic light scattering and small angle X-ray scattering results shown the formation of BSA/PEG2000-PE/Dx aggregates in the solution. Osmometry results shown that the addition of Dx to the BSA/PEG2000-PE system could successfully increase the COP, through the formation of BSA/PEG2000-PE/Dx aggregates. The BSA/PEG2000-PE/Dx solutions attained COPÂ =Â 15Â mm Hg, representing 60% of COP measured for healthy adults.
Journal: Biophysical Chemistry - Volume 134, Issues 1â2, April 2008, Pages 34-38