کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5372074 1503977 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
pH modulation of transport properties of alamethicin oligomers inserted in zwitterionic-based artificial lipid membranes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
pH modulation of transport properties of alamethicin oligomers inserted in zwitterionic-based artificial lipid membranes
چکیده انگلیسی

Electric features of biological membranes are major determinants of the function and physiological manifestation of membrane-penetrating peptides, and such features are prone to be modulated by the properties of the surrounding aqueous medium. In this work, we demonstrate that pH plays crucial roles in modulating electric characteristics of zwitterionic-based artificial lipid membranes. The effect of pH on electrical properties of such membranes was probed by evaluating the transport properties of embedded alamethicin oligomers over a wide range of pH values (i.e., 0.65, 2.08, 2.94, 7 and 10.1). Our data strongly support the paradigm of a pH-dependent variation of the surface and membrane dipole potential which, in conjunction with possible lateral pressure effects within the lipid membrane, lead to a non-monotonic modulation of the electrical conductance of alamethicin oligomers. As expected, pH modulation of transport properties through the alamethicin oligomer is more visible for narrower pores (that is, the 1st conductive state) with slightly better cation selectivity as compared to larger oligomers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 130, Issue 3, November 2007, Pages 139-147
نویسندگان
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