Markov models and dynamical fingerprints: Unraveling the complexity of molecular kinetics

► Conformational dynamics of large biomolecules represented by Markov models. ► Quantitative prediction of the dynamical fingerprints of correlation experiments. ► The setup of the experiment determines which processes can be measured. ► The slowest observed process does not always correspond to the overall folding rate. ► Optimal experimental setup and observable(s) using molecular simulation and Markov models.