|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5432071||1508829||2017||13 صفحه PDF||سفارش دهید||دانلود رایگان|
Magnetofluorescent carbon quantum dots (MCQDs) have attracted significant attention in biomedical studies due to their major role in cancer photothermal therapeutics. We synthesized the FeN@CQDs with intrinsic photoluminescent and magnetic properties with a green, hydrothermal method. These magnetofluorescent FeN@CQDs were conjugated with a folic acid and riboflavin (Rf-FA-FeN@CQDs) as the light-triggered theranostics for simultaneous photothermal therapy (PTT) and photodynamic therapy (PDT). In order to reduce Rf-FA-FeN@CQDs biological toxicity, we used a highly efficient cross-linking reaction to incorporate Rf-FA-FeN@CQDs nanostructures into polymer nanospheres. Doxorubicin, an anticancer drug, was further incorporated into the GP-Rf-FA-FeN@CQDs to form GP-Rf-FA-FeN@CQDs-DOX to enable targeted drug delivery. The uptake into cancer cells and the intracellular location of the GP-Rf-FA-FeN@CQDs-DOX were observed by confocal laser scanning microscopy. The results of both inÂ vitro and inÂ vivo experiments reveal that the developed can deliver anti-cancer drugs to target cells, release them intracellular upon NIR irradiation, and effectively eliminate tumors through chemo-photo synergistic therapeutic effect.
Journal: Carbon - Volume 118, July 2017, Pages 752-764