کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434359 1509141 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The application of silver nano-particles on developing potential treatment for chronic rhinosinusitis: Antibacterial action and cytotoxicity effect on human nasal epithelial cell model
ترجمه فارسی عنوان
استفاده از نانو ذرات نقره در توسعه درمان بالقوه برای رینوسینوزیت مزمن: اثر ضد باکتریایی و اثر سیتوتوکسی سمی در مدل سلول های اپیتلیال بینی
کلمات کلیدی
رینویوزیت مزمن، نانو ذرات نقره، سلول اپیتلیال بینی بینی انسان، سمیت مسمومیت، عامل ضد باکتری،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- The 10 nm silver nano-particles (AgNPs) could penetrate cell membrane into RPMI2650 cell.
- The 5 ppm of AgNPs had better biocompatibility on RPMI2650 cells.
- The 5 ppm of AgNPs possessed 80% of antibacterial effect on S. aureus.
- The 5 ppm of AgNPs is a promising antibacterial agent for treating chronic rhinosinusitis.

Chronic rhinosinusitis (CRS) has raised attentions both in many countries due to its high relapsing rate and the resistance of certain treatments especially antibiotics application on both acute and chronic bacterial rhinosinusitis. The aim of this research is stressing on developing an effective alternative treatment for treating CRS and reducing the use of antibiotics to avoid further resistance forming. The antibacterial functions of silver nano-particles (AgNPs) are well known according to previous reports and studies. However, for developing a suitable treatment for further clinical application, a variety of AgNPs cell cytotoxicity experiments and AgNPs antibacterial properties experiments were examined in vitro in this study. For imitating the clinical condition of CRS, the human nasal epithelial cell line (RPMI2650) has chosen as experimental model. Moreover, Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) were selected for antibacterial function experiments. The analytical results demonstrated that 5 ppm of AgNPs not only maintains > 80% of cell activity to RPMI2650, but also possesses > 80% of antibacterial function to S. aureus and 100% of antibacterial function to E. coli. Therefore, 5 ppm of AgNPs might be considered as a promising antibacterial agent for treating CRS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 80, 1 November 2017, Pages 624-630
نویسندگان
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