کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434381 1509143 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scaffolds for Bone Tissue Engineering: State of the art and new perspectives
ترجمه فارسی عنوان
داربست برای مهندسی استخوان: وضعیت و دیدگاه های جدید
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- Bone complicated larger defects can impair healing, thus needing additional treatments.
- Tissue engineering has emerged as a promising alternative for bone regeneration.
- Scaffolds design should meet biological, structural and composition criteria.
- Vascularization of engineered scaffold is critical to enhance osteo-integration.
- Rapid Prototyping allows to fabricate tailored, biomimetic-shaped 3D structures.

This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering.Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail.Attention is then focused on conventional and Rapid Prototyping scaffold manufacturing techniques. Conventional manufacturing approaches are subtractive methods where parts of the material are removed from an initial block to achieve the desired shape. Rapid Prototyping techniques, introduced to overcome standard techniques limitations, are additive fabrication processes that manufacture the final three-dimensional object via deposition of overlying layers. An important improvement is the possibility to create custom-made products by means of computer assisted technologies, starting from patient's medical images.As a conclusion, it is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval.PUBMED search terms utilized to write this review were: “Bone Tissue Engineering”, “regenerative medicine”, “bioactive scaffolds”, “biomimetic scaffolds”, “3D printing”, “3D bioprinting”, “vascularization” and “dentistry”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 78, 1 September 2017, Pages 1246-1262
نویسندگان
, , , , , , ,