کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5434425 | 1509143 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Halloysite nanotubes were used to strengthen a gelatin scaffold.
- The mechanical properties of the gelatin scaffold were enhanced significantly.
- Long-time drug release to fight infection and pain.
- The obtained composite scaffold was suitable for bone treatment.
Mechanical properties and anti-infection are two of the most concerned issues for artificial bone grafting materials. Bone regeneration porous scaffolds with sustained drug release were developed by freeze-drying the mixture of nanosized drug-loaded halloysite nanotubes (HNTs) and gelatin. The scaffolds showed porous structure and excellent biocompatibility. The mechanical properties of the obtained composite scaffolds were enhanced significantly by HNTs to >Â 300%, comparing to those of gelatin scaffold, and match to those of natural cancellous bones. The ibuprofen-loaded HNTs incorporated in the scaffolds allowed extended drug release over 100Â h, comparing to 8Â h when directly mixed the drug into the gelatin scaffold. The biological properties of the composite scaffolds were investigated by culturing MG63 cells on them. The HNTs/gelatin scaffolds with excellent mechanical properties and sustained drug release could be a promising artificial bone grating material.
The addition of HNT can strengthen the gelatin scaffold obviously, and provide a persistent drug release.153
Journal: Materials Science and Engineering: C - Volume 78, 1 September 2017, Pages 362-369