کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434704 1509142 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and characterization of in situ chitosan/polyethylene glycol fumarate/thymol hydrogel as an effective wound dressing
ترجمه فارسی عنوان
آماده سازی و مشخص کردن کیتوزان / پلی اتیلن گلیکول فومارات / هیدروژل تیمول به عنوان یک پوشش پانسمان مؤثر
کلمات کلیدی
پانسمان زخم، مخلوط کردن کیتوزان، پلی اتیلن گلیکول فومارات، تیمول،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- Antibacterial wound dressings based on chitosan/polyethylene glycol fumarate/thymol were fabricated.
- Thymol was used as a pharmaceutical additive to improve the antibacterial activity of polymeric films.
- An improvement in physicochemical properties of thymol free films was confirmed.
- These blend films were suggested for infected wounds with moderate exudates in wound dressing applications.

In the present study, polyethylene glycol fumarate (PEGF) was synthesized as a component of blend solutions via polycondensation polymerization and characterized by different tests in order to determine its functional groups and its physical properties included melting and crystallization temperature, enthalpy of fusion and average molecular weights. Wound dressing films based on chitosan (Ch), PEGF and thymol (Th) were fabricated by solvent casting method with different formulations contained 80%(w/w) chitosan and 20%(w/w) PEGF as polymeric components and different amounts of thymol consisted of 0, 0.6, 1.2 and 1.8%(v/v) as pharmaceutical additives of blend solutions. These films were evaluated by different essential tests included Fourier transform infrared spectroscopy (FTIR), tensile testing, water vapor transmission rate (WVTR), water vapor uptake, equilibrium water uptake, water solubility, swelling, scanning electron microscopy (SEM) and antibacterial activity tests. The blend film contained 1.8%(v/v) thymol demonstrated optimal properties included acceptable mechanical properties, better absorption of water vapor or liquid water, higher water vapor transmission rate and air permeability, acceptable water solubility, superior swelling level, more porous structures and rough surfaces and the excellent antibacterial activity against both gram-negative and gram-positive bacteria which make it a suitable candidate for wound dressing applications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 79, 1 October 2017, Pages 66-75
نویسندگان
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