کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5435009 | 1509147 | 2017 | 8 صفحه PDF | دانلود رایگان |
- A simple, non-toxic and cost-effective way to improve water stability of zein nanofibers was proposed.
- Electrospun zein/ethyl cellulose nanofibers with improved water stability and mechanical strength were prepared.
- Indomethacin was homogeneously distributed in the zein/ethyl cellulose nanofibers with no aggregation or cluster.
- The zein/ethyl cellulose nanofibers presented a sustained drug release profile, following Fickican diffusion mechanism.
A simple and cost-effective way to prepare water-stable zein-based nanofibers for potential drug delivery was presented in this article. Corn protein zein was co-electrospun with hydrophobic ethyl cellulose. Indomethacin, as a model drug, was incorporated in situ into the composite nanofibers. Scanning electron microscopy and element mapping revealed the morphologies of drug-loaded nanofibers and drug distribution, respectively. Fourier transform infrared spectra confirmed the physical blending among the components. Differential scanning calorimetry and X-ray diffraction demonstrated the physical state of drug and polymers in the nanofiber matrix. The composite nanofibers showed a sustained diffusion-controlled release according to the results of in vitro dissolution tests.
Journal: Materials Science and Engineering: C - Volume 74, 1 May 2017, Pages 86-93