کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5438151 | 1398181 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance
ترجمه فارسی عنوان
ساخت و مشخصه داربست های پیچیده ای هیدروکسی آپاتیت با تخلخل سلسله مراتبی از ویژگی های مختلف برای عملکرد مطلوب زیست فعال
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کلمات کلیدی
هیدروکسی آپاتیت داربست، تخلخل سلسله مراتبی، ویژگی ظاهری، عملکرد بیولوژیکی، مهندسی بافت استخوانی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
چکیده انگلیسی
To improve the biological performance of hydroxyapatite scaffolds in bone tissue engineering, graphite was used as porogen to create additional micro/nanoporosity to macroporosity, resulting in hierarchical porosity. For maximum imitation of natural bone structures, scaffolds with different porosity features were fabricated using micron/nano-sized graphite. The sintering profile of graphite treated scaffolds was optimised to reduce the influence of shrinkage. To confirm the porosity features, the micro/nanostructures of scaffolds were characterised by scanning electron microscopy and Brunauer-Emmett-Teller method. Considering that hydroxyapatite is resistant to biodegradation in vivo, the degradation rate of scaffolds in modified simulated body fluid was examined. Furthermore, biological evaluations based on myoblasts were carried out to investigate the influence of porosity features on the essential performance such as adhesion, proliferation and differentiation. The results indicate that the scaffolds with dominant microporosity and little nanoporosity formed inside had high potential for clinical applications due to improved performance in bioactivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 43, Issue 1, Part A, January 2017, Pages 336-344
Journal: Ceramics International - Volume 43, Issue 1, Part A, January 2017, Pages 336-344
نویسندگان
Zhichao Chen, Xianglin Zhang, Yang Yang, Kui Zhou, Nicholas Wragg, Yang Liu, Mark Lewis, Changqing Liu,