کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5462809 | 1517179 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile preparation of surface functional carbon dots and their application in doxorubicin hydrochloride delivery
ترجمه فارسی عنوان
آماده سازی چسبنده های نقطه کربن سطح کارکرد و کاربرد آنها در تحویل دوکوروبیسین هیدروکلراید
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
A novel form of carbon dots (PEG-CDs) was prepared by using one-step hydrothermal synthesis with glycine as the precursor and polyethylene glycol (PEG)-2000 as the surface modifier. The prepared PEG-CDs were characterized with HRTEM, XRD, PL, FTIR and UV. The results showed that they were quasi spherical particles with a diameter of approximately 12Â nm and had a fine fluorescence property, good water solubility, favorable stability and high quantum yield with 28.58%. Doxorubicin hydrochloride (DOX) as a potential anti-cancer drug was loaded on the PEG-CDs. The drug loading capacity was 24.25Â mg/g and the encapsulation efficiency was 77.23% at pH 9.0 with 36Â h of dialysis; DOX release in PBS system with a pH of 5.5 could reach up to 76.67% in 23Â h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 209, 15 December 2017, Pages 360-364
Journal: Materials Letters - Volume 209, 15 December 2017, Pages 360-364
نویسندگان
Xin Zhang, Yongbo Wang, Wenwei Liu, Xuhua Liang, Boni Si, Enzhou Liu, Xiaoyun Hu, Jun Fan,