کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5499328 | 1533496 | 2016 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gamma and ion-beam irradiation of DNA: Free radical mechanisms, electron effects, and radiation chemical track structure
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gamma and ion-beam irradiation of DNA: Free radical mechanisms, electron effects, and radiation chemical track structure Gamma and ion-beam irradiation of DNA: Free radical mechanisms, electron effects, and radiation chemical track structure](/preview/png/5499328.png)
چکیده انگلیسی
The focus of our laboratory's investigation is to study the direct-type DNA damage mechanisms resulting from γ-ray and ion-beam radiation-induced free radical processes in DNA which lead to molecular damage important to cellular survival. This work compares the results of low LET (γ-) and high LET (ion-beam) radiation to develop a chemical track structure model for ion-beam radiation damage to DNA. Recent studies on protonation states of cytosine cation radicals in the N1-substituted cytosine derivatives in their ground state and 5-methylcytosine cation radicals in ground as well as in excited state are described. Our results exhibit a radical signature of excitations in 5-methylcytosine cation radical. Moreover, our recent theoretical studies elucidate the role of electron-induced reactions (low energy electrons (LEE), presolvated electrons (epreâ), and aqueous (or, solvated) electrons (eaqâ)). Finally DFT calculations of the ionization potentials of various sugar radicals show the relative reactivity of these species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 128, November 2016, Pages 60-74
Journal: Radiation Physics and Chemistry - Volume 128, November 2016, Pages 60-74
نویسندگان
Michael D. Sevilla, David Becker, Anil Kumar, Amitava Adhikary,