کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5500594 1534299 2017 49 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stem cell therapies in age-related neurodegenerative diseases and stroke
ترجمه فارسی عنوان
درمان با سلول های بنیادی در بیماری های عصبی مصنوعی و سکته مغزی
کلمات کلیدی
سالخورده، سلول بنیادی، بیماری های نوروژنیک، سکته مغزی پلاستیک خود تجدید،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke. These diseases share similar neuropathological changes, such as the formation of misfolded proteins, oxidative stress, loss of neurons and synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair capacity, and motor and/or cognitive deficiencies. In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases. Aging not only renders patients more susceptible to these disorders, but also attenuates their self-repair capabilities. In addition, low drug responsiveness and intolerable side effects are major challenges in the prevention and treatment of senile diseases. Thus, stem cell therapies-characterized by cellular plasticity and the ability to self-renew-may be a promising strategy for aging-related brain disorders. Here, we review the common pathophysiological changes, treatments, and the promises and limitations of stem cell therapies in age-related neurodegenerative diseases and stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 34, March 2017, Pages 39-50
نویسندگان
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