کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501292 | 1534847 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice
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کلمات کلیدی
Cathepsin ZIL-6HSDCTSZIL-1βDcxHprtIba-1 - IBA-1immunoreactive - ایمنی فعالinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancehonestly significant difference - تفاوت صادقانه قابل توجه استdoublecortin - دوچرخهdentate gyrus - شکنج دندانه دارionized calcium-binding adapter molecule 1 - ملکول آداپتور اتصال دهنده کلسیم یونیزه 1hypoxanthine phosphoribosyltransferase - هیپوکسانتین فسفریبوسیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is well established that adult neurogenesis in the hippocampus declines with age. Our previous studies have suggested that progranulin (PGRN) has a facilitative effect on hippocampal neurogenesis. We have also shown that PGRN plays a role in suppressing excessive neuroinflammatory responses in the cortex and thalamus after brain injury and aging, respectively. However, the roles of PGRN in modulating neurogenesis and neuroinflammatory responses in the hippocampus of aged animals are not yet understood. In the present study, we investigated neurogenesis and neuroinflammation-related responses in the hippocampus of young (15-week-old) and old (135-week-old) wild-type and PGRN-deficient male mice. Neurogenesis in the dentate gyrus of the hippocampus markedly declined with age, and there was no significant difference between the genotype. The number of CD68-positive activated microglia and the expression of lysosomal genes in the hippocampus were significantly increased with age, and PGRN deficiency further increased them. The expression of pro-inflammatory genes was also increased with age, and PGRN deficiency significantly enhanced some of them. These results suggest that PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 95, September 2017, Pages 1-8
Journal: Experimental Gerontology - Volume 95, September 2017, Pages 1-8
نویسندگان
Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara,