کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501326 | 1534848 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin](/preview/png/5501326.png)
چکیده انگلیسی
Due to its ability to cross the epidermis and reach the upper dermis where it causes cumulative DNA damage and increased oxidative stress, UVB is considered the most harmful component of sunlight to the skin. The consequences of chronic exposition to UVB are related to photoaging and photocarcinogenesis. There are limitations to the study of human skin aging and for this reason the use of models is required. Human dermal fibroblasts submitted to mild and repeated doses of UVB are considered a versatile model to study UVB effects in the process of skin photoaging, which depends on the accumulation of senescent cells, in particular in the dermis. Here we provide updated information about the current model of UVB-induced senescence with special emphasis on the process of protein quality control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 94, August 2017, Pages 78-82
Journal: Experimental Gerontology - Volume 94, August 2017, Pages 78-82
نویسندگان
Maria Cavinato, Pidder Jansen-Dürr,