Frailty - From concept to clinical practice

Ageing per se has long been thought to be unalterable and being the major cause for most chronic diseases and frailty. Significant increases in the understanding of cellular senescence now challenge this. Interventions may delay age-related conditions and thus compressing late-life morbidity with positive consequences for public health. Besides pharmacological interventions, lifestyle choices including diet and physical activity can optimize the biology of ageing and extend healthy life span.