Microparticle formation by platelets exposed to high gas pressures - An oxidative stress response

The studies show that high pressures of N2, Ar and He, but not N2O, SF6 or hydrostatic pressure (HP), will interact with NADPH oxidase (NOX) derived superoxide (O2−) to yield singlet oxygen (O2*). Subsequent interactions with NOS2 derived products result in actin S-nitrosylation (SNO-actin) that enhances cytoskeletal turnover ultimately causing microparticle (MPs) formation.107