کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5501891 1534934 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagy as a regulator of cardiovascular redox homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Autophagy as a regulator of cardiovascular redox homeostasis
چکیده انگلیسی
Autophagy is a highly regulated process involving the removal of damaged proteins and organelles from cells and tissues through a lysosomal-mediated pathway. Accumulating evidence suggests that autophagy is necessary to maintain redox homeostasis. Here, we explore the connection between autophagy and reactive oxygen species (ROS). In particular, we discuss how oxidant-dependent signaling can modulate autophagic flux and how autophagy can, in turn, modulate ROS levels. Finally, we discuss how a decline or disruption of autophagy might contribute to redox-dependent cardiovascular pathology and help fuel the age-dependent decline in cardiovascular function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 109, August 2017, Pages 108-113
نویسندگان
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