کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504383 | 1536282 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation](/preview/png/5504383.png)
چکیده انگلیسی
The FBXO25 mediates degradation of ELK-1 and thus inhibits transcriptional activation of immediate early genes (iEG). Here we show that FBXO25 regulates yet another node of this signaling pathway, by decreasing MAPK/ERK activity. We show that induction of FBXO25 reduced ERK1/2 phosphorylation independently of MEK1/2. Accordingly, in HAP1 FBXO25 knockout cells (FBXO25KO), we observed that upon PMA treatment ERK1/2 was more active than in parental cells. An increase in cell proliferation under receptor mediated activation of the ERK signaling pathway in FBXO25KO cells was also observed. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 621, 1 May 2017, Pages 38-45
Journal: Archives of Biochemistry and Biophysics - Volume 621, 1 May 2017, Pages 38-45
نویسندگان
Felipe R. Teixeira, Adriana O. Manfiolli, Nichelle A. Vieira, Ana Carla Medeiros, Priscila de O. Coelho, Dimitrius Santiago Guimarães, Deborah Schechtman, Marcelo D. Gomes,