HIV-1 matrix-31 membrane binding peptide interacts differently with membranes containing PS vs. PI(4,5)P2

Cartoon representation of MA31myr insertion into a negatively charged membrane, based upon neutron reflectivity results. The location of the 7 positively charged amino acid residues in the HBR from AA20-32 are visualized by + signs with nearby negatively charged lipid headgroups (- signs). The charged amino acids in the AA2-19 stretch are visualized as +- pairs. The last AA32 is visualized near bulk water to allow the remainder of the MA131 protein to reside in water.55