کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5509142 | 1538400 | 2017 | 63 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strategies to identify natural antisense transcripts
ترجمه فارسی عنوان
استراتژی برای شناسایی رونویسی های ضد انسداد طبیعی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Natural antisense transcripts, originally considered as transcriptional noises arising from so-called “junk DNAâ³, are recently recognized as important modulators for gene regulation. They are prevalent in nearly all realms of life and have been found to modulate gene expression positively or negatively. By affecting almost all stages of gene expression range from pre-transcriptional, transcriptional and post-transcriptional to translation, NATs are fundamentally involved in various biological processes. However, compared to increasing huge data from transcriptional analysis especially high-throughput sequencing technologies (such as RNA-seq), limited functional NATs (around 70) are so far reported, which hinder our advanced comprehensive understanding for this field. Hence, efficient strategies for identifying NATs are urgently desired. In this review, we discussed the current strategies for identifying NATs, with a focus on the advantages, disadvantages, and applications of methods isolating functional NATs. Moreover, publicly available databases for NATs were also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 132, January 2017, Pages 131-151
Journal: Biochimie - Volume 132, January 2017, Pages 131-151
نویسندگان
Yulong Sun, Dijie Li, Ru Zhang, Shang Peng, Ge Zhang, Tuanmin Yang, Airong Qian,