کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5510392 | 1538982 | 2017 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comparison of blood nitric oxide metabolites and hemoglobin functional properties among diving mammals
ترجمه فارسی عنوان
مقایسه متابولیتهای نیتریک اکسید خون و خواص عملکرد هموگلوبین در بین پستانداران غواصی
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کلمات کلیدی
IEFFeNOSNOGSNOP50PO2DPGS-nitrosationHBAGSHN50Nitric oxide (nitrogen monoxide)nNO2,3-diphosphoglycerate - 2،3-دی فسفوگلسراتOxygen - اکسیژنisoelectrofocusing - ایزو الکترو فوکوس کردنRespiration - تنفسAdaptation - سازگاری(زیست شناسی)Signaling - سیگنالینگDiving - غواصیOxygen partial pressure - فشار بخار اکسیژنNitrosamine - نیترواسمینNitrite - نیتریتHemoglobin - هموگلوبینHypoxia - هیپوکسیGlutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The ability of marine mammals to hunt prey at depth is known to rely on enhanced oxygen stores and on selective distribution of blood flow, but the molecular mechanisms regulating blood flow and oxygen transport remain unresolved. To investigate the molecular mechanisms that may be important in regulating blood flow, we measured concentration of nitrite and S-nitrosothiols (SNO), two metabolites of the vasodilator nitric oxide (NO), in the blood of 5 species of marine mammals differing in their dive duration: bottlenose dolphin, South American sea lion, harbor seal, walrus and beluga whale. We also examined oxygen affinity, sensitivity to 2,3-diphosphoglycerate (DPG) and nitrite reductase activity of the hemoglobin (Hb) to search for possible adaptive variations in these functional properties. We found levels of plasma and red blood cells nitrite similar to those reported for terrestrial mammals, but unusually high concentrations of red blood cell SNO in bottlenose dolphin, walrus and beluga whale, suggesting enhanced SNO-dependent signaling in these species. Purified Hbs showed similar functional properties in terms of oxygen affinity and sensitivity to DPG, indicating that reported large variations in blood oxygen affinity among diving mammals likely derive from phenotypic variations in red blood cell DPG levels. The nitrite reductase activities of the Hbs were overall slightly higher than that of human Hb, with the Hb of beluga whale, capable of longest dives, having the highest activity. Taken together, these results underscore adaptive variations in circulatory NO metabolism in diving mammals but not in the oxygenation properties of the Hb.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 205, March 2017, Pages 35-40
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 205, March 2017, Pages 35-40
نویسندگان
Angela Fago, Daniel Garcia Parraga, Elin E. Petersen, Niels Kristensen, Lea Giouri, Frank B. Jensen,