کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5510597 | 1539267 | 2017 | 13 صفحه PDF | دانلود رایگان |
The aim of the present investigation was to assess the immune status in yellowfin seabream (Acanthopagrus latus) exposed to different concentrations of phenanthrene (Phe) for 14Â days. In addition, the Phe accumulation in the fish muscle was measured during the experiment. Fish were injected with different concentrations (0, 2, 20 and 40Â mg/kg) of Phe and samples were taken from tissue and blood of fish 1, 4, 7 and 14Â days after injection. Exposure of fish to Phe caused a significant decrease in white blood cells, C3 and C4 levels, lysosomal membrane stability, lysozyme activity after 4Â days and antibacterial activity after 7Â days of the experiment. In contrast, cortisol level significantly increased after 4Â days. The concentration of Phe in fish muscle increased rapidly after 4Â days. The main tissue changes observed in the head kidney including increase in melanomacrophage centers (MMCs), empty spaces between cells and hemorrhage. The degree of tissue changes ranged from normal to moderate in Phe-treated fish. The size and number of MMCs in treated fish were significantly higher than control. In conclusion, Phe toxicity in yellowfin seabream can induce increased cortisol level, tissue changes and immune suppression.
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 195, May 2017, Pages 78-90