کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5511022 1539379 2017 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate
چکیده انگلیسی
Tumor tissues are known to harbor hypoxic areas. The hypoxic microenvironment promotes angiogenesis. Hypoxic tumor cells also manifest genome instability. DNA damage repair pathways, such as double-strand break repair, mismatch repair and base excision repair are known to be altered during hypoxia. This review is focused on the non-heme Fe(II) and 2-oxoglutarate-dependent dioxygenases which are involved in repair of DNA alkylation adducts. Activities of these DNA repair enzymes are completely oxygen-dependent and little information is available about inhibition of these enzymes during hypoxia. While impairment of function of non-heme dioxygenase during tumor hypoxia has been implicated in different studies, the possible outcomes with respect to mutagenesis and genomic instability are explored here.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 49, January 2017, Pages 21-25
نویسندگان
,