Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor

• We assessed whether the P. xylostella ABCC2 protein is a functional Bt receptor.
• Px-ABCC2 was transformed into Drosophila and expressed in the midgut.
• Expressing Px-ABCC2 rendered Drosophila susceptible to Cry1Ac toxin and protoxin.
• M. sexta cadherin peptides synergised Cry1Ac more effectively than P. xylostella peptides.