Controlled release of antibiotic amoxicillin drug using carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) hydrogel

- Carboxymethyl cellulose-cl-p(lactic acid-co-itaconic acid) hydrogel has been prepared under microwave irridiation.
- Different spectral techniques have confirmed the formation of hydrogel.
- The reaction parameters such as microwave power, time, monomer concentration, crosslinker, initiator and pH of the solution were optimized to obtain the maximum yield.
- The drug loading and release behaviour of hydrogel was investigated.
- Hydrogel was also found as an excellent antibacterial agent against gram positive Staphylococcus aureus.

In this paper, microwave assisted preparation of carboxymethyl cellulose-cl-poly(lactic acid-co-itaconic acid) (CMC-cl-P(LA-co-IA)) hydrogel was reported via facile graft copolymerization using N,N1-methylene-bis-acrylamide (MBA) and potassium persulphate as cross linker and initiator. Different reaction parameters were optimized to achieve good yield. The formation of hydrogel was confirmed by characterization techniques such as Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy etc. The antimicrobial activities of the hydrogel were studied against Staphylococcus aureus and Escherichia coli. About 95% killing of bacteria was recorded after 24 h. The controlled release of amoxicillin drug from hydrogel was evaluated as a function of pH and time. Maximum drug release of 98% was recorded at 2.2 pH after 7 h. The kinetic studies showed non-Fickian diffusion of the drug.

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