کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5513375 1541201 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The power of bioluminescence imaging in understanding host-pathogen interactions
ترجمه فارسی عنوان
قدرت تصویربرداری بیولوژیکی در درک تعاملات پاتوژن میزبان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- The role of bioluminescent imaging in models of infection is discussed.
- Light-producing reporter animals are used to study host response to infection.
- Methodology for developing neonatal somatic light producing reporter mice described.

Infectious diseases are one of the leading causes of death worldwide. Modelling and understanding human infection is imperative to developing treatments to reduce the global burden of infectious disease. Bioluminescence imaging is a highly sensitive, non-invasive technique based on the detection of light, produced by luciferase-catalysed reactions. In the study of infectious disease, bioluminescence imaging is a well-established technique; it can be used to detect, localize and quantify specific immune cells, pathogens or immunological processes. This enables longitudinal studies in which the spectrum of the disease process and its response to therapies can be monitored. Light producing transgenic rodents are emerging as key tools in the study of host response to infection. Here, we review the strategies for identifying biological processes in vivo, including the technology of bioluminescence imaging and illustrate how this technique is shedding light on the host-pathogen relationship.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 127, 15 August 2017, Pages 69-78
نویسندگان
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