کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5518400 | 1543953 | 2017 | 4 صفحه PDF | دانلود رایگان |
- First report to associate the asp110ala polymorphisms in the Ninj1 gene with nerve damage in Tamil Nadu, South India.
- Ninjurin 1 gene CC Homozygous as a risk of leprosy.
- Genetic variants were observed in leprosy patient's disability grade, DGÂ >Â 2 followed by DGÂ >Â 1.
BackgroundLeprosy is a chronic granulomatous infection caused by Mycobacterium leprae, the obligate intracellular bacillus that attacks cutaneous tissue and can damage the peripheral nervous system.AimTo determine the association between the Ninjurin 1 gene asp110ala (rs2275848) polymorphism in nerve damage leprosy patients.Meterials and methodsWe carried the 234 leprosy patients along with equal number of controls with age and gender-matched were recruited. Genotyping was done by polymerase chain reaction/restriction fragment length polymorphism and confirmation of sequence.ResultsThe CC genotype (ala/ala) had a higher risk of developing nerve disability when compared those carrying the AA genotype (asp/asp) and the variation observed were statistically significant at PÂ <Â 0.05.ConclusionThe Ninjurin 1 gene asp110ala genetic variation may be a risk of nerve damage among leprosy patients in south India.
Journal: Meta Gene - Volume 12, June 2017, Pages 18-21