کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5518427 | 1543955 | 2016 | 5 صفحه PDF | دانلود رایگان |
Sirtuin 1 (SIR1) is a NADÂ +Â -dependent nuclear deacetylase that is involved in various metabolic pathways affecting energy homeostasis. In this investigation, we aimed to study the association of three SIRT1 gene single nucleotide polymorphisms (SNPs); rs7895833 A/G, rs7069102 C/G and rs2273773 C/T, located on the promotor, intron and exon regions respectively, with essential hypertension and type 2 diabetes mellitus (T2DM). The three SNPs were genotyped using polymerase chain reaction with confronting two pair of primers (PCR-CTPP) method in a group of non-diabetic essential hypertensive patients, a group of patients with essential hypertension and T2DM, in addition to a group of healthy controls. The results of the investigation revealed that G-allele of rs7895833 A/G increased in the patients compared to the controls (PÂ =Â 0.046), [OR (95% CI) was 0.72 (0.5-1)] and GG genotype and G-allele frequencies of rs7069102 C/G, were significantly higher in patients compared to the controls (PÂ =Â 0.0045 & <Â 0.0001, respectively). Regarding rs2273773 C/T, TT-genotype and T-allele increased significantly in the patients compared to the controls (PÂ =Â 0.016 & 0.04, respectively), respectively). No significant differences in the genotypes or alleles frequencies were found between the patient groups. We conclude that genetic polymorphisms in SIRT1 gene might play a role in the pathogenesis of essential hypertension and both essential hypertension and T2DM share similar pathogenic mechanism.
Journal: Meta Gene - Volume 10, December 2016, Pages 8-12