کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5520134 1544559 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis - Mission possible?
ترجمه فارسی عنوان
درمان درمانی فیزیولوژیک مبتنی بر نانومدیاسین برای درمان سرطان پروستات - ماموریت ممکن است؟
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal carcinomatosis (PC). Over the past decade, a lot of effort has been put both in the academia and clinic in developing IP therapeutic approaches that maximize local efficacy while limiting systemic side effects. Also nanomedicines are under investigation for the treatment of tumors confined to the peritoneal cavity, due to their potential to increase the peritoneal retention and to target drugs to the tumor sites as compared to free drugs. Despite the progress reported by multiple clinical studies, there are no FDA approved drugs or formulations for specific use in the IP cavity yet. This review discusses the current clinical management of PC, as well as recent advances in nanomedicine-based IP delivery. We address important challenges to be overcome towards designing optimal nanocarriers for IP therapy in vivo.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 108, 1 January 2017, Pages 13-24
نویسندگان
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