کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5521607 1545310 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperComparison of mucoadhesive and cohesive features of poly(acrylic acid)-conjugates respective their molecular mass
ترجمه فارسی عنوان
مقایسه ویژگی های مکوژژژژژی و انسجام پلی (اسید آکریلیک)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

ObjectivesThis study aimed to assess the impact of molecular mass as well as the differences between poly(acrylic acid)-thiol-conjugates (PAA100,250,450 KDa) on their mucoadhesive and cohesive qualities.MethodsCovalent attachment of cysteine (CYS), cysteamine (CYSM) and l-gluthathione (GSH) to poly(acrylic acid) was achieved by formation of amide bonds between primary amino group of the amino acid (in the case of cysteine and glutathione), respectively the amino group of the aminothiol cysteamine and carboxylic acid group of the polymer. Obtained polymer conjugates were evaluated in regard to their safety profile, mucoadhesive properties on the buccal mucosa by rotating cylinder, tensile strength and rheological investigations, respectively. Furthermore, stability, cohesive and water uptake studies were performed.Key findingsMucoadhesive studies revealed that maximum detachment force of PAACYS450 was 24.3-fold higher in comparison to the respective controls. Stability studies revealed for PAACYS450 a 50.2-fold higher stability compared to controls.ConclusionTaken together, among all polymers tested, PAACYS450 evinced the most favorable qualities regarding mucoadhesion and cohesion, followed by PAACYSM450 and PAACYS250.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 113, April 2017, Pages 149-156
نویسندگان
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