کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5521657 1545314 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperFreezing and glass transitions upon cooling and warming and ice/freeze-concentration-solution morphology of emulsified aqueous citric acid
ترجمه فارسی عنوان
فریزر و انتقال شیشه ای پس از خنک سازی و گرم شدن و مورفولوژی محلول یخ / یخ زدگی-محلول اسید سیتریک آبلیمو
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Although freeze-induced phase separation and the ice/FCS (freeze-concentration solution) morphology of aqueous solutions play an important role in fields ranging from life sciences and biotechnology to geophysics and high-altitude ice clouds, their understanding is far from complete. Herein, using differential scanning calorimetry (DSC) and optical cryo-microscope (OC-M), we have studied the freezing and glass transition behavior and the ice/FCS morphology of emulsified 10-60 wt% CA (citric acid) solutions in the temperature region of ∼308 and 153 K. We have obtained a lot of new result which are understandable and unclear. The most essential understandable results are as follows: (i) similar to bulk CA/H2O, emulsified CA/H2O also freezes upon cooling and warming and (ii) the ice/FCS morphology of frozen drops smaller than ∼3-4 μm is less ramified than that of frozen bulk solutions. Unclear results, among others, are as follows: (i) in contrast to bulk solutions, which produce one freezing event, emulsified CA/H2O produces two freezing events and (ii) in emulsions, drop concentration is not uniform. Our results demonstrate that DSC thermograms and OC-M images/movies are mutually supplementary and allow us to extract important information which cannot be gained when DSC and OC-M techniques are used alone.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 109, December 2016, Pages 49-60
نویسندگان
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