کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529305 1401692 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleProtective effects of thymoquinone and avenanthramides on titanium dioxide nanoparticles induced toxicity in Sprague-Dawley rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original articleProtective effects of thymoquinone and avenanthramides on titanium dioxide nanoparticles induced toxicity in Sprague-Dawley rats
چکیده انگلیسی

The protective effect of thymoquinone (TQ), the major active ingredient of Nigella sativa seeds, and avenanthramides (AVA) enriched extract of oats on titanium dioxide naonparticles (TiO2 NPs) induced toxicity and oxidative stress in Sprague-Dawley (SD) rats was investigated. Sixty rats were divided into 6 equal groups. The first, second, third, fourth and fifth groups received TiO2 NPs, TiO2 NPs and TQ, TiO2 NPs and AVA, TQ only, or AVA only for 6 weeks. The sixth group served as the control. Exposure to TiO2 NPs resulted in increased liver enzyme markers, oxidative stress indices, tumor necrosis factor alpha (TNF-α) and DNA damage. Histopathological alterations were also observed in the liver, brain, lung, kidney, heart and testes. Co-administration of TQ and AVA with TiO2 NPs decreased the level of liver enzymes, oxidative stress, TNF-α and DNA damage. Furthermore, TQ and AVA increased the total antioxidant and glutathione (GSH) levels. In conclusion, TiO2 NPs induce hazardous effects in different organs and are closely related to oxidative stress. TQ and AVA have antioxidative and anti-inflammatory effect against the detrimental effect of TiO2 NPs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 213, Issue 1, January 2017, Pages 13-22
نویسندگان
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