کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5530611 1401753 2016 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
ReviewThe entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained
چکیده انگلیسی


- The unfolded protein response plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum stress.
- ER and mitochondrial dysfunction are common themes in neurodegenerative diseases.
- Targeting these pathways provides an opportunity to develop new therapeutics for neurodegenerative disease.

Endoplasmic reticulum (ER) and mitochondrial function have both been shown to be critical events in neurodegenerative diseases. The ER mediates protein folding, maturation, sorting as well acts as calcium storage. The unfolded protein response (UPR) is a stress response of the ER that is activated by the accumulation of misfolded proteins within the ER lumen. Although the molecular mechanisms underlying ER stress-induced apoptosis are not completely understood, increasing evidence suggests that ER and mitochondria cooperate to signal cell death. Similarly, calcium-mediated mitochondrial function and dynamics not only contribute to ATP generation and calcium buffering but are also a linchpin in mediating cell fate. Mitochondria and ER form structural and functional networks (mitochondria-associated ER membranes [MAMs]) essential to maintaining cellular homeostasis and determining cell fate under various pathophysiological conditions. Regulated Ca2+ transfer from the ER to the mitochondria is important in maintaining control of pro-survival/pro-death pathways. In this review, we summarize the latest therapeutic strategies that target these essential organelles in the context of neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 60, Issue 3, September 2016, Pages 218-234
نویسندگان
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