Pericytes are heterogeneous in their origin within the same tissue

- Pericytes differ in their embryonic origin between tissues.
- Pericytes from within the same tissue may be heterogeneous in their origin.
- A subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage.

Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.