Development and diabetes on the fly

- Review use of Drosophila melanogaster as a model to study diabetes mellitus
- Review insulin signaling throughout development and aging in the fly
- Besides glucose homeostasis, insulin signals growth, nutrition and lifespan

We review the use of a model organism to study the effects of a slow course, degenerative disease: namely, diabetes mellitus. Development and aging are biological phenomena entailing reproduction, growth, and differentiation, and then decline and progressive loss of functionality leading ultimately to failure and death. It occurs at all biological levels of organization, from molecular interactions to organismal well being and homeostasis. Yet very few models capable of addressing the different levels of complexity in these chronic, developmental phenomena are available to study, and model organisms are an exception and a welcome opportunity for these approaches. Genetic model organisms, like the common fruit fly, Drosophila melanogaster, offer the possibility of studying the panoply of life processes in normal and diseased states like diabetes mellitus, from a plethora of different perspectives. These long-term aspects are now beginning to be characterized.