کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5535557 1551550 2017 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sperm Mitochondrial Function is Affected by Stallion Age and Predicts Post-Thaw Motility
ترجمه فارسی عنوان
عملکرد میوکاردیون اسپرم تحت تأثیر سن استالیونی قرار گرفته و پیش بینی حرکت پس از خاموش شدن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
Sperm motility and quality decline with stallion age and sperm preservation, but the mechanisms of functional deficit have not been explained. We tested the hypothesis that mitochondrial deficits underlie age- and cryopreservation-related deficits in stallion fertility by measuring mitochondrial function, motility, and reactive oxygen species (ROS) in 88 frozen-thawed ejaculates from 19 stallions of varying ages. As expected with increasing age, total sperm motility, progressive motility, and average path velocity decreased, and ROS production increased. For every unit increase in oxygen consumption, there was a 77% increase in the odds of sperm movement (P < .05), confirming the link between mitochondrial functionality and motility. In addition, the rate of mitochondrial oxygen consumption increased from 4 years of age to a peak at 12 years of age and decreased steadily thereafter (P < .05). This confirms the importance of mitochondrial functionality for overall sperm health and motility, implicating mitochondrial dysfunction as a major contributor to sperm aging and cryopreservation damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Equine Veterinary Science - Volume 50, March 2017, Pages 52-61
نویسندگان
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