کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548847 1556595 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic targets: Chronic alcohol actions
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Synaptic targets: Chronic alcohol actions
چکیده انگلیسی


- Chronic alcohol exposure produces neuroadaptation at GABA and glutamate synapses.
- The main effects are altered GABAAR/NMDAR expression, composition and/or function.
- It is hypothesized that these adaptations play a role in addictive drinking behavior.

Alcohol acts on numerous cellular and molecular targets to regulate neuronal communication within the brain. Chronic alcohol exposure and acute withdrawal generate prominent neuroadaptations at synapses, including compensatory effects on the expression, localization and function of synaptic proteins, channels and receptors.The present article reviews the literature describing the synaptic effects of chronic alcohol exposure and their relevance for synaptic transmission in the central nervous system. This review is not meant to be comprehensive, but rather to highlight the effects that have been observed most consistently and that are thought to contribute to the development of alcohol dependence and the negative aspects of withdrawal. Specifically, we will focus on the major excitatory and inhibitory neurotransmitters in the brain, glutamate and GABA, respectively, and how their neuroadaptations after chronic alcohol exposure contributes to alcohol reinforcement, dependence and withdrawal.This article is part of the Special Issue entitled “Alcoholism”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 122, 1 August 2017, Pages 85-99
نویسندگان
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