کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5551077 1402938 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids
ترجمه فارسی عنوان
یک روز سیب برای جلوگیری از تشکیل سرطان: کاهش خطر ابتلا به سرطان با فلاونوئیدها
کلمات کلیدی
سیب، شیمی درمانی سرطان، فلورین، نوع 2 گلوکز مایع،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Apple polyphenols and cell proliferation.
- Apple polyphenols inhibit cell migration and invasion.
- Apple polyphenols induce apoptotic cancer cell death.
- Signaling molecules and disease protection effects of phloretin.
- Apple polyphenols induce anticancer effects in animal models.

The purpose of this review is to update and discuss key findings from in vitro and in vivo studies on apple and its biocompounds, with a special focus on its anticancer role. Several studies have proposed that apple and its extracts exhibit a variety of biological functions that may contribute to health benefits including beneficial effects against chronic heart and vascular disorders, respiratory and pulmonary dysfunction, diabetes, obesity, and cancer. In this review, we summarize the molecular mechanism(s) of various components in apple, as established in previous studies that indicated their growth-inhibitory effects in various cancer cell types. Moreover, an attempt is made to delineate the direction of future studies that could lead to the development of apple components as a potent chemopreventive/chemotherapeutic agent against cancer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food and Drug Analysis - Volume 25, Issue 1, January 2017, Pages 119-124
نویسندگان
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