کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5551129 1402940 2017 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers
ترجمه فارسی عنوان
پیشرفت های اخیر در تحویل دهان و دندان داروها و محصولات زیست فعال طبیعی با استفاده از نانوذرات لیپید جامد به عنوان حامل
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- SLNs are nanosystems for the delivery of drugs with controlled release kinetics.
- We highlight the recent progress in the study of oral SLNs for disease treatment.
- SLNs are developed by solid lipids and emulsifiers generally recognized as safe.
- Both drugs and natural compounds are suitable to be orally delivered by SLNs.

Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper the oral delivery of many labile drugs. The GI epithelium also contributes to poor permeability for numerous drugs. Drugs with poor aqueous solubility have difficulty dissolving in the GI tract, resulting in low bioavailability. Nanomedicine provides an opportunity to improve the delivery efficiency of orally administered drugs. Solid lipid nanoparticles (SLNs) are categorized as a new generation of lipid nanoparticles consisting of a complete solid lipid matrix. SLNs used for oral administration offer several benefits over conventional formulations, including increased solubility, enhanced stability, improved epithelium permeability and bioavailability, prolonged half-life, tissue targeting, and minimal side effects. The nontoxic excipients and sophisticated material engineering of SLNs tailor the controllable physicochemical properties of the nanoparticles for GI penetration via mucosal or lymphatic transport. In this review, we highlight the recent progress in the development of SLNs for disease treatment. Recent application of oral SLNs includes therapies for cancers, central nervous system-related disorders, cardiovascular-related diseases, infection, diabetes, and osteoporosis. In addition to drugs that may be active cargos in SLNs, some natural compounds with pharmacological activity are also suitable for SLN encapsulation to enhance oral bioavailability. In this article, we systematically introduce the concepts and amelioration mechanisms of the nanomedical techniques for drug- and natural compound-loaded SLNs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food and Drug Analysis - Volume 25, Issue 2, April 2017, Pages 219-234
نویسندگان
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