کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5555360 | 1559747 | 2017 | 9 صفحه PDF | دانلود رایگان |
- Pterostilbene (Pte) attenuates myocardial I/R (MI/R) injury via reducing oxidative/nitrative stress.
- Pte treatment reduces MI/R injury-induced inflammatory response.
- The activation of eNOS and the inhibition of p38 MAPK are involved in the cardioprotective effects of Pte.
Recent studies have shown that pterostilbene (Pte) confers protection against myocardial ischemia/reperfusion injury. The oxidative/nitrative stress and inflammation induce injury after myocardial ischemia/reperfusion. The present study was designed to evaluate whether treatment with Pte attenuates oxidative/nitrative stress and inflammation in myocardial ischemia/reperfusion (MI/R). Rats were subjected to 30 min of myocardial ischemia and 3 h of reperfusion, and the rats were administered with vehicle or Pte. The results showed that Pte (10 mg/kg) dramatically improved cardiac function and reduced myocardial infarction and myocardial apoptosis following MI/R. As an indicator of oxidative/nitrative stress, myocardial ONOOâ content was markedly reduced after Pte treatment. And, Pte led to a dramatic decrease in superoxide generation and malondialdehyde (MDA) content and a dramatic increase in superoxide dismutase (SOD) activity. In addition, Pte treatment significantly reduced p38 MAPK activation and the expression of iNOS and gp91phox and increased phosphorylated eNOS expression. Pte treatment dramatically decreased myocardial TNF-α, and IL-1β levels and myeloperoxidase (MPO) activity. Furthermore, ONOOâ suppression by either Pte or uric acid (UA), an ONOOâ scavenger, reduced myocardial injury. In conclusion, Pte exerts a protective effect against MI/R injury by suppressing oxidative/nitrative stress. These results provide evidence that Pte might be a therapeutic approach for the treatment of MI/R injury.
Journal: International Immunopharmacology - Volume 43, February 2017, Pages 7-15