کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555529 1559748 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia
چکیده انگلیسی


- Piperine significantly inhibited LPS-induced TNF-α, IL-6, IL-1β, and PGE2 production in BV2 cells.
- Piperine dose-dependently inhibited LPS-induced NF-κB activation.
- Piperine was found to amplify the expression of Nrf2 and HO-1 up-regulated by LPS.
- The inhibition of inflammatory mediators by piperine can be reversed by transfection with Nrf2 siRNA.

Piperine, the chief alkaloid isolated from Piper nigrum, has been known to have anti-inflammatory effect. However, the effects of piperine on neuroinflammation have not been reported. In the present study, we evaluated the effects of piperine on neuroinflammation in BV2 microglia and investigated the molecular mechanism. The results showed that piperine significantly inhibited LPS-induced TNF-α, IL-6, IL-1β, and PGE2 production in BV2 cells. Western blot analysis showed that piperine dose-dependently inhibited LPS-induced NF-κB activation. Furthermore, piperine was found to amplify the expression of Nrf2 and HO-1 up-regulated by LPS. In addition, the inhibition of inflammatory mediators by piperine can be reversed by transfection with Nrf2 siRNA. In conclusion, piperine inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway. These results indicated that piperine may be a promising agent for the treatment of neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 42, January 2017, Pages 44-48
نویسندگان
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