کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5556382 1560367 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots
چکیده انگلیسی

Ethnopharmacological relevanceCaesalpinia digyna Rottler (Caesalpiniaceae) roots have been used traditionally for soothing nerves, as nervine tonic and febrifuge. The aim of the present study was to isolate the antianxiety constituent(s) from C. digyna roots following bioactivity guided fractionation approach.Material and methodsBioactive fraction F4 was subjected to column chromatography to get three sub-fractions (F4.1-F4.3) and a compound CD2. CD1 and CD2 were characterized using standard spectral techniques. Three fractions (F4.1-F4.3) were evaluated for antianxiety activity in mice using EPM. An effective dose of the antianxiety principle was optimized, and its activity was, further evaluated using open field and mirror chamber tests.ResultsCD1 and CD2 characterized as bergenin, exhibited significant antianxiety activity at 80 mg/kg, po which was statistically comparable to that of diazepam (2 mg/kg, po). However, F4.1-F4.3 were observed to be devoid of antianxiety activity. Bergenin also exhibited significant antianxiety activity in open field and mirrored chamber tests.ConclusionsBergenin, isolated from roots of C. digyna, exhibits significant antianxiety activity at 80 mg/kg, po in three different models for evaluating antianxiety activity. This activity of bergenin is being reported for the first time.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 195, 4 January 2017, Pages 182-187
نویسندگان
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