کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5556580 1560480 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
15th Annual Meeting of the Safety Pharmacology Society: Focus on traditional sensory systems
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
15th Annual Meeting of the Safety Pharmacology Society: Focus on traditional sensory systems
چکیده انگلیسی

IntroductionThis report summarizes and comments key talks on the five traditional senses (ear, vestibular system, vision, taste, olfaction, and touch) which were delivered during the 2015 Annual Meeting of the Safety Pharmacology (SP) Society.Areas coveredThe functional observational battery (FOB) can detect major candidate drug liabilities only on ear, touch and vision. Anatomy, physiology, pharmacology, and pathology notions on each sensory system introduce speaker talks. Techniques for evaluating drug effects on hearing functions are reviewed. Nonclinical approaches to assess vestibular toxicity leading to balance deficits are presented. Retinal explants studied with multielectrode arrays allow the identification of drug liability sites on the retina. Routinely performed Safety Pharmacology assays are not powered to address candidate drug-induced disturbances on taste and smell. This weakness needs correction since unintended pharmacological impairment of these sensorial functions may have serious health consequences. Neuropathy produced by chemotherapeutic agents may cause multiple sensorial perception distortions.ConclusionsSafety Pharmacology studies should ensure the safety of any candidate drug on the five sensorial systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological and Toxicological Methods - Volume 83, January–February 2017, Pages 55-71
نویسندگان
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