کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558483 1561149 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aluminum exposure for one hour decreases vascular reactivity in conductance and resistance arteries in rats
ترجمه فارسی عنوان
قرار گرفتن آلومینیوم برای یک ساعت، واکنش پذیری عروقی را در رگ های هدایت و مقاومت در موش های صحرایی کاهش می دهد
کلمات کلیدی
آلومینیوم، قرار گرفتن در معرض حاد، واکنش پذیری عروقی، استرس اکسیداتیو،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- One hour of aluminum exposure decreases vascular reactivity.
- Vascular imbalance after aluminum exposure is related to increased oxidative stress.
- Enhanced NO release is the first step against the effects of Al at vascular system.

AimsAluminum (Al) is an important environmental contaminant; however, there are not enough evidences of Al-induced cardiovascular dysfunction. We investigated the effects of acute exposure to aluminum chloride (AlCl3) on blood pressure, vascular reactivity and oxidative stress.Methods and resultsMale Wistar rats were divided into two groups: Untreated: vehicle (ultrapure water, ip) and AlCl3: single dose of AlCl3 (100 mg/kg,ip). Concentration-response curves to phenylephrine in the absence and presence of endothelium, the nitric oxide synthase inhibitor l-NAME, the potassium channel blocker tetraethylammonium, and the NADPH oxidase inhibitor apocynin were performed in segments from aortic and mesenteric resistance arteries. NO released was assessed in aorta and reactive oxygen species (ROS), malondialdehyde, non-protein thiol levels, antioxidant capacity and enzymatic antioxidant activities were investigated in plasma, aorta and/or mesenteric arteries. After one hour of AlCl3 exposure serum Al levels attained 147.7 ± 25.0 μg/L. Al treatment: 1) did not affect blood pressure, heart rate and vasodilator responses induced by acetylcholine or sodium nitroprusside; 2) decreased phenylephrine-induced vasoconstrictor responses; 3) increased endothelial modulation of contractile responses, NO release and vascular ROS production from NADPH oxidase; 4) increased plasmatic, aortic and mesenteric malondialdehyde and ROS production, and 5) decreased antioxidant capacity and affected the antioxidant biomarkers non-protein thiol levels, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase enzymatic activities.ConclusionAlCl3-acute exposure reduces vascular reactivity. This effect is associated with increased NO production, probably acting on K+ channels, which seems to occur as a compensatory mechanism against Al-induced oxidative stress. Our results suggest that Al exerts toxic effects to the vascular system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 313, 15 December 2016, Pages 109-118
نویسندگان
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