کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5558552 | 1561147 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation
ترجمه فارسی عنوان
آسیب حاد ریه و بیماری کمبود هوایی پایین در یک مدل خرگوش استنشاق کلر
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Chlorine is a pulmonary toxicant to which humans can be exposed through accidents or intentional releases. Acute effects of chlorine inhalation in humans and animal models have been well characterized, but less is known about persistent effects of acute, high-level chlorine exposures. In particular, animal models that reproduce the long-term effects suggested to occur in humans are lacking. Here, we report the development of a rabbit model in which both acute and persistent effects of chlorine inhalation can be assessed. Male New Zealand White rabbits were exposed to chlorine while the lungs were mechanically ventilated. After chlorine exposure, the rabbits were extubated and were allowed to survive for up to 24Â h after exposure to 800Â ppm chlorine for 4Â min to study acute effects or up to 7Â days after exposure to 400Â ppm for 8Â min to study longer term effects. Acute effects observed 6 or 24Â h after inhalation of 800Â ppm chlorine for 4Â min included hypoxemia, pulmonary edema, airway epithelial injury, inflammation, altered baseline lung mechanics, and airway hyperreactivity to inhaled methacholine. Seven days after recovery from inhalation of 400Â ppm chlorine for 8Â min, rabbits exhibited mild hypoxemia, increased area of pressure-volume loops, and airway hyperreactivity. Lung histology 7Â days after chlorine exposure revealed abnormalities in the small airways, including inflammation and sporadic bronchiolitis obliterans lesions. Immunostaining showed a paucity of club and ciliated cells in the epithelium at these sites. These results suggest that small airway disease may be an important component of persistent respiratory abnormalities that occur following acute chlorine exposure. This non-rodent chlorine exposure model should prove useful for studying persistent effects of acute chlorine exposure and for assessing efficacy of countermeasures for chlorine-induced lung injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 315, 15 January 2017, Pages 1-11
Journal: Toxicology and Applied Pharmacology - Volume 315, 15 January 2017, Pages 1-11
نویسندگان
Sadiatu Musah, Connie F. Schlueter, David M. Jr., Karen S. Powell, Andrew M. Roberts, Gary W. Hoyle,