کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560165 | 1561740 | 2017 | 19 صفحه PDF | دانلود رایگان |
- Food contact materials can release into food intentionally added substances or not.
- FCM hazard assessment is currently performed only with single started substances.
- Released chemicals are difficult to predict and identify/quantify.
- Bioassays used cytotoxicity, genotoxicity and hormonal activity are described.
- Bioassays are relevant tools to assess hazard of the finished packaging.
This review focuses on the use of in vitro bioassays for the hazard assessment of food contact materials (FCM) as a relevant strategy, in complement to analytical methods. FCM may transfer constituents to foods, not always detected by analytical chemistry, resulting in low but measurable human exposures. Testing FCM extracts with bioassays represents the biological response of a combination of substances, able to be released from the finished materials. Furthermore, this approach is particularly useful regarding the current risk assessment challenges with unpredicted/unidentified non-intentionally added substances (NIAS) that can be leached from the FCM in the food. Bioassays applied to assess hazard of different FCM types are described for, to date, the toxicological endpoints able to be expressed at low levels; cytotoxicity, genotoxicity and endocrine disruption potential. The bioassay strengths and relative key points needed to correctly use and improve the performance of bioassays for an additional FCM risk assessment is developed. This review compiles studies showing that combining both chemical and toxicological analyses presents a very promising and pragmatic tool for identifying new undesirable NIAS (not predicted) which can represent a great part of the migrating substances and/or “cocktail effect”.
Journal: Food and Chemical Toxicology - Volume 105, July 2017, Pages 429-447