کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560176 | 1561740 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice
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کلمات کلیدی
CDC125IUdRAOOICCVAMLLNALocal lymph node assay (LLNA)DNFBdpmACDAllergic contactNTPLocal lymph node assay - آزمایش گره لنفاوی محلیNational Toxicology Program - برنامه سم شناسی ملیdisintegrations per minute - تخریب در دقیقهAllergic contact dermatitis - درماتیت تماس آلرژیکstimulation index - شاخص تحریکCenters for Disease Control and Prevention - مراکز کنترل و پیشگیری از بیماریInteragency Coordinating Committee on the Validation of Alternative Methods - کمیته هماهنگی بین ادارات اعتبار سنجی روش های جایگزین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, resulting in temporary contamination of 15 percent of the state's tap water and causing significant dermal exposure. The current studies were undertaken to determine whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or sensitization. BALB/c female mice were treated daily for 3 consecutive days by direct epicutaneous application of 25 μL of various concentrations of crude MCHM or MCHM to the dorsum of each ear. A mouse ear-swelling test was used to determine irritancy potential and was undertaken in combination with the standardized Local Lymph Node Assay (LLNA) to determine skin sensitizing potential. MCHM was found to produce skin irritation at concentrations above 20% and did not produce sensitization. Crude MCHM also produced irritation, although weaker, and in addition was found to be a weak to moderate skin sensitizer. The results are discussed in terms of potential human health hazard.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 105, July 2017, Pages 99-105
Journal: Food and Chemical Toxicology - Volume 105, July 2017, Pages 99-105
نویسندگان
Victor J. Johnson, Scott S. Auerbach, Michael I. Luster, Suramya Waidyanatha, Scott A. Masten, Mary S. Wolfe, Florence G. Burleson, Gary R. Burleson, Dori R. Germolec,