دانلود مقالات ISI درباره Iccvam + ترجمه فارسی

وضعیت مورد نیاز آزمایشات سمیت سیستمیک و داده ها توسط سازمان های نظارتی ایالات متحده مورد استفاده قرار می گیرد

Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies

Keywords: Acute systemic toxicity; Alternative approaches; Non-animal methods; Regulatory requirements; LD50; LC50; In vitro; In silico; AEGL; Acute Exposure Guideline Level; CBER; FDA Center for Biologics Evaluation and Research; CDER; FDA Center for Drug Evaluati

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

مدل های پیش بینی شده برای سمیت سیستمیک حاد حاد: یک کارگاه برای پر کردن شکاف از تحقیقات به مقررات

Predictive models for acute oral systemic toxicity: A workshop to bridge the gap from research to regulation

Keywords: QSAR; Read-across; Acute oral toxicity; ICCVAM; Workshop;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

یک مرور کلی از تکنیک های فعلی برای آزمایش سمیت چشم

An overview of current techniques for ocular toxicity testing

Keywords: BCOP; Bovine Cornea Opacity Permeability (test/assay); CAMVA; Chorioallantoic membrane vascular assay; CEET; Chicken enucleated eye test; CK; Cytokeratin; CM; Cytosensor Microphysiometer (test); CPSC; Consumer Product Safety Commission; CTPA; Cosmetic, To

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

بررسی اعتبار درون / بین آزمایشگاهی بر روی گونه های اکسایش واکنش پذیر برای ارزیابی ایمنی شیمیایی با استفاده از دو شبیه ساز خورشیدی مختلف

Intra-/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators

Keywords: 3T3 NRU PT; 3T3 neutral red uptake phototoxicity test; 8-MOP; 8-methoxypsoralen; CV; coefficient of variation; ECVAM; Europe Center for the Validation of Alternative Methods; GLP; Good Laboratory Practice; ICCVAM; Interagency Coordinating Committee on the

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

SkinEthic™ HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions

Keywords: BLR; Between Laboratory Reproducibility; CAS RN; Chemical Abstracts Service Registry Number; Cat 1; UN GHS classification for chemicals causing irreversible effects on the eye/serious damage to the eye; Cat 2; UN GHS classification for chemicals causing r

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2019 سفارش ترجمه

Human adipose-derived stem cells (ADSC) and human periodontal ligament stem cells (PDLSC) as cellular substrates of a toxicity prediction assay

Keywords: Cytotoxicity; Adipose-derived stem cells; Periodontal ligament stem cells; In vitro toxicity prediction; ADSC; adipose-derived stem cells; BMSC; bone marrow-derived stem cells; DMEM; Dulbecco's Modified Eagle's Medium; D-PBS; Dulbecco's Phosphate Buffered

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice

Keywords: 4-Methylcyclohexanemethanol; Local Lymph Node Assay (LLNA); Allergic contact; Dermatitis (ACD); Dermal hypersensitivity; Dermal irritancy; Elk River spill; ACD; allergic contact dermatitis; AOO; acetone:olive oil (4:1, v/v); CDC; Centers for Disease Contr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Aligning the 3Rs with new paradigms in the safety assessment of chemicals

Keywords: 3Rs; replacement, refinement and reduction of animals in research; AOP; adverse outcome pathway; EURL-ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; ICCVAM; Interagency Coordinating Committee on the Validation of Alternativ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

BK/TD models for analyzing in vitro impedance data on cytotoxicity

Keywords: ICCVAM; the Interagency Coordinating Committee on the Validation of Alternative Methods; ECVAM; European Centre for Validation of Alternative Methods; OECD; Organisation for Economic Co-operation and Development; ECIS; electric cell-substrate impedance se

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Allergenicity evaluation of fragrance mix and its ingredients by using ex vivo local lymph node assay-BrdU endpoints

Keywords: AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; AOO; Acetone: Olive Oil; EC3; estimated concentration; FBS; Fetal Bovine Serum; ICCVAM; Interagency Coordinating Committee on the Validation of Alternative Methods; IFN; inter

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

A robotic BG1Luc reporter assay to detect estrogen receptor agonists

Keywords: CCi; CertiChem, Inc.; CS; calf serum; DMSO; dimethyl sulfoxide; E2; 17β-estradiol; EA; estrogenic activity; EC50; half-maximal response of a test substance in its dose-response curve; EDC; endocrine disrupting chemical; EFM; EA-free medium; ER; estrogen

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of long term storage on tobacco smoke particulate matter in in vitro genotoxicity and cytotoxicity assays

Keywords: ANCOVA; analysis of covariance; BAT; British American Tobacco; COM; Committee on Mutagenicity; CORESTA; Cooperation Centre for Scientific Research Relative to Tobacco; DMSO; dimethyl sulfoxide; GLP; Good Laboratory Practice; GVP; gas vapour phase; IC50; t

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation

Keywords: ANOVA; analysis of variance; BCOP; bovine corneal opacity and permeability test; BLV; between laboratory variability; CE; cosmetics Europe the personal care association; ECVAM; European centre for the validation of alternative methods; EIT; Eye Irritation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations

Keywords: CLP; European Council requirements for Classification, Labeling and Packaging of substances and mixtures; EC; the concentration of chemical required to induce a 3-fold stimulation index in the local lymph node assay; ECHA; European Chemicals Agency; EPA;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

Keywords: LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; WLR; within laboratory reproducibility; BLR; between laborat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Research perspectives for pre-screening alternatives to animal experimentation

Keywords: MEIC; Multicenter Evaluation of In vitro Cytotoxicity program; REACH; Registration, Evaluation, Authorisation and Restriction of Chemicals system; HTS; high throughput screening; MTS; medium throughput screening; ED; endocrine disruptor; ADME; absorption,

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه